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  • Title: Quantitative determination of pharmaceutical drug formulations by near-infrared spectroscopic imaging.
    Author: Kolomiets O, Hoffmann U, Geladi P, Siesler HW.
    Journal: Appl Spectrosc; 2008 Nov; 62(11):1200-8. PubMed ID: 19007460.
    Abstract:
    Over the last decade Fourier transform infrared (FT-IR) and near-infrared (NIR) spectroscopic imaging with focal plane array (FPA) detectors have proved powerful techniques for the rapid visualization of samples by a combination of spectroscopic and spatial information. Using these methods, selected sample areas can be analyzed with reference to the identification and localization of chemical species by FT-IR spectroscopy in the transmission or attenuated total reflection (ATR) mode and by NIR spectroscopy in diffuse reflection with a lateral resolution in the micrometer range. The present communication focuses on the quantitative determination of the active ingredient composition of a solid drug formulation by NIR spectroscopic imaging with a focal plane array detector and the results obtained are compared to the quantitative data obtained by conservative light-fiber NIR spectroscopic diffuse reflection measurements with a single-element detector. The communication also addresses the issue of penetration depth of NIR radiation into the investigated solid material.
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