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Title: Mitochondrial energetic metabolism: a simplified model of TCA cycle with ATP production. Author: Nazaret C, Heiske M, Thurley K, Mazat JP. Journal: J Theor Biol; 2009 Jun 07; 258(3):455-64. PubMed ID: 19007794. Abstract: Mitochondria play a central role in cellular energetic metabolism. The essential parts of this metabolism are the tricarboxylic acid (TCA) cycle, the respiratory chain and the adenosine triphosphate (ATP) synthesis machinery. Here a simplified model of these three metabolic components with a limited set of differential equations is presented. The existence of a steady state is demonstrated and results of numerical simulations are presented. The relevance of a simple model to represent actual in vivo behavior is discussed.[Abstract] [Full Text] [Related] [New Search]