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  • Title: Dynamic measurements of total hepatic blood flow with Phase Contrast MRI.
    Author: Yzet T, Bouzerar R, Baledent O, Renard C, Lumbala DM, Nguyen-Khac E, Regimbeau JM, Deramond H, Meyer ME.
    Journal: Eur J Radiol; 2010 Jan; 73(1):119-24. PubMed ID: 19008062.
    Abstract:
    BACKGROUND/AIMS: To measure total hepatic blood flow including portal and proper hepatic artery flows as well as the temporal evolution of the vessel's section during a cardiac cycle. METHODS: Twenty healthy subjects, with a mean age of 26 years, were explored. Magnetic resonance imaging blood flow measurements were carried out in the portal vein and the proper hepatic artery. MR studies were performed using a 1.5T imager (General Electric Medical Systems). Gradient-echo 2D Fast Cine Phase Contrast sequences were used with both cardiac and respiratory gatings. Data analysis was performed using a semi-automatic software built in our laboratory. RESULTS: The total hepatic flow rate measured was 1.35+/-0.18L/min or 19.7+/-4.6mL/(minkg). The proper hepatic artery provided 19.1% of the total hepatic blood flow entering the liver. Those measurements were in agreement with earlier studies using direct measurements. Mean and maximum velocities were also assessed and a discrepancy between our values and the literature's Doppler data was found. Measurements of the portal vein area have shown a mean variation, defined as a "pulsatility" index of 18% over a cardiac cycle. CONCLUSIONS: We report here proper hepatic artery blood flow rate measurements using MRI. Associated with portal flow measurements, we have shown the feasibility of total hepatic flowmetry using a non-invasive and harmless technique.
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