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  • Title: Exploiting the natural metabolic diversity of Streptomyces venezuelae to generate unusual reduced macrolides.
    Author: Park JW, Oh HS, Jung WS, Park SR, Han AR, Ban YH, Kim EJ, Kang HY, Yoon YJ.
    Journal: Chem Commun (Camb); 2008 Nov 30; (44):5782-4. PubMed ID: 19009080.
    Abstract:
    An unusual set of reduced macrolide antibiotics was discovered by combination of organic synthesis and a biosynthetic approach using the unique metabolic diversity of Streptomyces venezuelae; two unnatural 16-membered ring macrolides are also created by employing this bio-catalyst.
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