These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Idiopathic pulmonary fibrosis and emphysema in smokers.
    Author: Silva DR, Gazzana MB, Barreto SS, Knorst MM.
    Journal: J Bras Pneumol; 2008 Oct; 34(10):779-86. PubMed ID: 19009210.
    Abstract:
    OBJECTIVE: To describe the clinical and functional findings recently reported in the medical literature for patients diagnosed with emphysema involving the upper lobes and idiopathic pulmonary fibrosis (IPF) involving the lower lobes. METHODS: Eleven patients with emphysema and IPF were identified retrospectively. All of the patients underwent high-resolution computed tomography of the lung and pulmonary function tests. RESULTS: Of the 11 patients, 8 were male and 3 were female. The mean age was 70.7 +/- 7.2 years (range, 61-86 years). All of the patients were smokers (mean smoking history, 61.5 +/- 43.5 pack-years). The mean values of forced vital capacity (FVC), forced expiratory volume in one second (FEV1) and FEV1/FVC were 72.1% +/- 12.7%, 68.2% +/- 11.9% and 74.4 +/- 10.8, respectively. Lung volumes were normal in 7 patients. A restrictive pattern was observed in 3 patients, and hyperinflation was present in one. The diffusing capacity was moderately-to-severely reduced in all of the patients (mean, 27.7% +/- 12.9% of predicted). Ten of the 11 patients performed the six-minute walk test. The mean distance covered was 358.4 +/- 143.1 m, and 9 of the 10 patients presented desaturation >or= 4%. Echocardiographic findings suggestive of pulmonary hypertension were present in 4 patients (mean systolic pulmonary artery pressure, 61.8 mmHg; range, 36-84 mmHg). CONCLUSIONS: The concomitant presence of emphysema and IPF causes characteristic changes on pulmonary function tests. The most significant finding is a discrepancy between diffusing capacity and spirometry results.
    [Abstract] [Full Text] [Related] [New Search]