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  • Title: Synthesis and in-vitro activity of new 1beta-methylcarbapenem derivatives as antibacterial agents.
    Author: Jung MH, Hong JH, Cho JH, Oh CH.
    Journal: Arch Pharm (Weinheim); 2008 Dec; 341(12):780-6. PubMed ID: 19009543.
    Abstract:
    The synthesis of a new series of 1beta-methylcarbapenems having pyrrolidine and piperidine moieties is described. Their in-vitro antibacterial activities against both Gram-positive and Gram-negative bacteria were tested and the effect of substituents on the pyrrolidine ring was investigated. A particular compound III b having an oxime-pyrrolidine moiety showed the most potent antibacterial activity.
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