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  • Title: Total parenteral nutrition-induced steatosis: reversal by parenteral lipid infusion.
    Author: Reif S, Tano M, Oliverio R, Young C, Rossi T.
    Journal: JPEN J Parenter Enteral Nutr; 1991; 15(1):102-4. PubMed ID: 1901098.
    Abstract:
    Prolonged use of total parenteral nutrition (TPN) may be associated with hepatic complications, primarily steatosis and cholestasis. A case is reported of an 18-year-old woman with chronic idiopathic intestinal pseudo-obstruction syndrome who was on prolonged home parenteral nutrition without lipid supplementation and developed steatosis. This finding was reversed by addition of lipid emulsion, at a dose of 0.5 g/kg/day, to the parenteral nutrition solution. The lack of lipid supplementation as a possible cause of steatosis, as well as other mechanisms of liver steatosis associated with TPN, are discussed.
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