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  • Title: Relationship between thyroid-stimulating hormone and insulin in euthyroid obese men.
    Author: Galofré JC, Pujante P, Abreu C, Santos S, Guillen-Grima F, Frühbeck G, Salvador J.
    Journal: Ann Nutr Metab; 2008; 53(3-4):188-94. PubMed ID: 19011282.
    Abstract:
    BACKGROUND/AIMS: Obesity has been associated with hypothyroidism and impaired insulin sensitivity. However, few studies have specifically addressed the association between insulin sensitivity and thyroid function. Our aim was to look for a relation between these 2 factors in a sample of obese males. METHODS: One hundred and forty-four euthyroid male obese patients--mean age 42.6 years, mean body mass index (BMI) 41.8--were enrolled in this cross-sectional study. The hospital study protocol at entrance included baseline serum thyroid-stimulating hormone (TSH), insulin and glucose concentrations. Data were studied using an age-adjusted simple and multivariate linear regression analysis with TSH as the dependent and insulin and BMI as the independent variables. RESULTS: Mean TSH and insulin were 1.6 and 21.2 mU/l, respectively. It was found that their relationship follows a regression model: TSH=1.725-0.019 (age) + 0.003 (insulin) + 0.017 (BMI). Further data showed a positive correlation between BMI and TSH (r= 0.22; p<0.05), as well as between serum baseline insulin (>10 mU/l) and TSH concentration (r=0.27; p<0.05). This association was stronger in patients with higher insulin values (>21.2 mU/l; r=0.40; p<0.01). However, negative correlations between age and insulin (r= -0.14; not significant) and age and TSH (r= -0.35; p<0.05) were observed. CONCLUSIONS: In obese males, insulin resistance is significantly related with impairment of thyroid function, and this situation seems to be attenuated with age.
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