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  • Title: A case of orbital Rosai-Dorfman disease responding to radiotherapy.
    Author: Cooper SL, Chavis PS, Fortney JA, Watkins JM, Caplan MJ, Jenrette JM.
    Journal: J Pediatr Hematol Oncol; 2008 Oct; 30(10):744-8. PubMed ID: 19011471.
    Abstract:
    Rosai-Dorfman disease (RDD) is a rare histiocytic disorder most often characterized by painless cervical lymphadenopathy, but it may also present with orbital disease. The clinical course of RDD is variable; it can be either relapsing-remitting or progressive, and the outcome relates to clinical location and treatment response. Orbital RDD can have an insidious onset and similar presentation to other ophthalmic conditions; this can result in a delayed diagnosis. Nearly all cases of orbital RDD cause visual disturbances and require treatment. Because orbital RDD is an uncommon presentation, a variety of interventions have been employed, including surgery, immunotherapy, chemotherapy, and radiotherapy. We present a case of salvage radiotherapy for progressive orbital RDD refractory to surgery and chemotherapy in a pediatric patient.
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