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  • Title: Hypothyroidism and dyshormonogenesis induced by D-penicillamine in children with Wilson's disease and healthy infants born to a mother with Wilson's disease.
    Author: Hanukoglu A, Curiel B, Berkowitz D, Levine A, Sack J, Lorberboym M.
    Journal: J Pediatr; 2008 Dec; 153(6):864-6. PubMed ID: 19014823.
    Abstract:
    Two siblings born to a mother with Wilson's disease, who was taking D-penicillamine, developed transient goitrous hypothyroidism. A prospective evaluation of 5 patients with Wilson's disease taking and not taking D-penicillamine for as long as 9.5 years showed subclinical hypothyroidism. D-penicillamine probably inhibited thyroperoxidase activity in utero in healthy infants and during childhood in patients with Wilson's disease.
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