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  • Title: Survival in type 2 diabetic patients in dialysis and the number of risk alleles in polymorphisms of the renin-angiotensin system genes.
    Author: Padró-Miquel A, Alía-Ramos P, González-Alvarez MT, Navarro-Moreno MA.
    Journal: Clin Biochem; 2009 Jan; 42(1-2):5-11. PubMed ID: 19014923.
    Abstract:
    OBJECTIVES: To study the combined effect of polymorphisms in genes of the renin-angiotensin system on mortality in type 2 diabetic patients in dialysis. DESIGN AND METHODS: From 1993 to 2007, we followed 89 patients from the start of dialysis until the end point, which was all-cause mortality. All patients were genotyped for the following polymorphisms: ACE (I/D), AGT (p.235M>T) and AGTR1 (g.1166A>C). The relative risks of death were examined by Cox-proportional hazard analysis after adjusting for age, sex, modality of dialysis, baseline and residual filtration rate, cardiovascular comorbidity, anemia, glycemic control, hypertension, nutritional status, risk of infection and dyslipidemia. RESULTS: We first assigned and quantified the number of risk alleles--D (I/D), M (p.235 M>T) and A (g.1166A>C)--each patient carried. The Cox-proportional hazard analysis showed that every single additional risk allele multiplied the mortality hazard ratio by 1.58 (95% CI: 1.16-2.15, P=0.003). CONCLUSIONS: Our data suggest a combined effect among the polymorphisms of the Renin-Angiotensin-System genes on mortality in type 2 diabetic patients undergoing dialysis.
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