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  • Title: Glycosphingolipid deficiency increases the sterol regulatory element-mediated gene transcription.
    Author: Ishitsuka R, Hirabayashi Y, Kobayashi T.
    Journal: Biochem Biophys Res Commun; 2009 Jan 09; 378(2):240-3. PubMed ID: 19017528.
    Abstract:
    A major feedback mechanism of cholesterol in transcription of cholesterol metabolism-related genes is mediated by sterol regulatory element-binding protein (SREBP). Involvement of glycosphingolipids (GSLs) in the SREBP pathway is unknown. In this study, we examined the effects of GSL depletion on SRE-mediated gene transcription using GSL-defective cells. We found that the content of mature SREBP, the transcriptional active form, is increased in the GSL-defective cells. Transcription of SREBP target genes and cholesterol synthesis are also induced in the GSL-defective cells. These results indicate that GSL deficiency up-regulates the SREBP pathway, pointing out the regulatory role of GSL in cholesterol homeostasis.
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