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Pubmed for Handhelds

PUBMED FOR HANDHELDS

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  • Title: Rapid detection of anti-chromatin autoantibodies in human serum using a portable electrochemical biosensor.
    Author: Konstantinov KN, Sitdikov RA, Lopez GP, Atanassov P, Rubin RL.
    Journal: Biosens Bioelectron; 2009 Mar 15; 24(7):1949-54. PubMed ID: 19019671.
    Abstract:
    The current system employed electrochemical sensor technology for the measurement of autoantibodies in human sera. Anti-chromatin antibodies are an early and sensitive indicator of systemic lupus erythematosus (SLE) and are typically quantified using enzyme-linked immunosorbent assays (ELISA). Electrochemical detection compared favorably with ELISA using a sample of 30 SLE sera (r=0.9), and non-specific binding by normal serum immunoglobulin was undetectable. The electrochemical sensor assay required <20min processing time and utilized a hand-held apparatus with a disposable electrode. These results demonstrate the applicability of this technology to the rapid measurement of a clinically relevant analyte with an apparatus of potential simplicity and low cost.
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