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  • Title: Macular spectral-domain optical coherence tomography in patients with X linked retinoschisis.
    Author: Gregori NZ, Berrocal AM, Gregori G, Murray TG, Knighton RW, Flynn HW, Dubovy S, Puliafito CA, Rosenfeld PJ.
    Journal: Br J Ophthalmol; 2009 Mar; 93(3):373-8. PubMed ID: 19019942.
    Abstract:
    AIM: To evaluate macular anatomy in patients with X linked retinoschisis (XLRS) using spectral-domain optical coherence tomography (SD-OCT). METHODS: Consecutive observational case series. Clinical features were obtained through retrospective chart review. Only eyes without prior surgical interventions and those scanned with SD-OCT were included. The OCT images were analysed. RESULTS: Fourteen eyes of seven males with XLRS scanned with SD-OCT, age 5 to 45 years, were identified. On clinical examination, stellate spoke-like cystic maculopathy was present in nine eyes, and an atrophic foveal lesion in five eyes. SD-OCT revealed cystoid spaces accounting for retinal splitting in the inner nuclear layer in 12 eyes, and outer plexiform layer in two eyes of one patient. A few small cysts, not accounting for the foveal splitting, were seen in the outer nuclear layer in four eyes and in the ganglion cell layer and/or nerve fibre layer in six eyes. CONCLUSIONS: SD-OCT localised the foveomacular retinoschisis in XLRS to the retinal layers deeper than the nerve fibre layer. In the present study, the foveomacular schisis was seen most frequently in the inner nuclear layer.
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