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  • Title: Sirolimus ameliorated post lung transplant chylothorax in lymphangioleiomyomatosis.
    Author: Ohara T, Oto T, Miyoshi K, Tao H, Yamane M, Toyooka S, Okazaki M, Date H, Sano Y.
    Journal: Ann Thorac Surg; 2008 Dec; 86(6):e7-8. PubMed ID: 19021963.
    Abstract:
    We report a successful case of sirolimus treatment for chylous pleural and peritoneal effusions of lymphangioleiomyomatosis after lung transplantation. A 32-year-old woman underwent living donor lung transplantation. Persistent chylous pleural and peritoneal effusions were seen postoperatively. Pleurodesis by intrathoracic injection of OK-432, minomycin, and somatostatine analog failed to control chylous effusions. However, sirolimus treatment reduced the amount of chylous drainage and improved both chylous pleural and peritoneal effusions.
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