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  • Title: Effect of different 1% chlorhexidine varnish regimens on mutans streptococci levels in saliva and dental biofilm.
    Author: Ribeiro LG, Hashizume LN, Maltz M.
    Journal: Am J Dent; 2008 Oct; 21(5):295-9. PubMed ID: 19024254.
    Abstract:
    PURPOSE: To evaluate in a randomized controlled study the effect of different 1% chlorhexidine (CHX) varnish regimens on levels of mutans streptococci (MS) in saliva and dental biofilm. METHODS: Subjects with MS < or = 10(5) CFU/ml saliva, 11-16 years old, were allocated into four groups: Group A (n = 14): one 1% CHX varnish application; Group B (n = 14): 1% CHX varnish was applied once daily on 3 consecutive days; Group C (n = 15): 1% CHX varnish was applied three times with an interval of 4 days between each application; and Group D (n = 12): placebo varnish was applied once daily on 3 consecutive days. Saliva and dental biofilm samples were collected at baseline and 1, 4, and 8 weeks after the final varnish application. RESULTS: After 1 week, a slight reduction in salivary levels of MS in Groups A, B, and C (-0.70, -0.90, and -0.41 log10 CFU/ml saliva, respectively) was observed, significant only in Groups A and B (P < 0.05). No difference in salivary levels of MS was observed between the experimental groups in the different experimental periods. After 1 week in the dental biofilm a significant increase in total bacterial counts was observed in all experimental groups while a significant decrease in the levels of MS was observed only in Group A.
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