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  • Title: Isotopic fractionation in thin-layer chromatography.
    Author: Heck H, Simon RL, Anbar M.
    Journal: J Chromatogr; 1977 Mar 21; 133(2):281-90. PubMed ID: 190246.
    Abstract:
    The thin-layer chromatography of imipramine on silica gel plates was studied in fifteen solvent systems. The mobility of imipramine labeled with deuterium in the methyl groups of the dimethylaminopropyl side chain differs markedly from that of unlabeled imipramine. Partial or complete separations between unlabeled and deuterated imipramine were observed in all basic and neutral solvent systems investigated, but not in weakly acidic solvents. Isotopic fractionations of imipramine were also found on alumina thin-layer plates, but were not detected in cellulose chromatography. In all thin-layer isotopic separations, the unlabeled compound migrates more rapidly than the deuterated molecule. These results can be explained by a stronger basicity of deuterated imipramine relative to its unlabeled counterpart.
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