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  • Title: Gene expression profile in the peripheral blood of patients with prostate cancer and benign prostatic hyperplasia.
    Author: Alonso V, Neves AF, Marangoni K, Faria PC, Freschi AP, Capaneli AC, Meola J, Goulart LR.
    Journal: Cancer Detect Prev; 2009; 32(4):336-7. PubMed ID: 19026495.
    Abstract:
    BACKGROUND: Prostate cancer consists of multifactorial and multifocal events, generating differential gene expression in tumor cells. METHODS: The molecular profile of 14 gene expression was analyzed through cDNA array in blood samples of patients with prostate cancer (PCa) and benign prostatic hyperplasia (BPH). RESULTS: Messenger RNA from patient's blood showed significant differences between PCa and BPH groups only for the NOS3 gene, with an occurrence chance for PCa5.8-fold higher than BPH disease. CONCLUSION: The NOS3 gene expression in the patient's blood may be used as a putative biomarker for prostate cancer.
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