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  • Title: Determination of intact oxaliplatin in human plasma using high performance liquid chromatography-tandem mass spectrometry.
    Author: Zhang W, Seymour L, Chen EX.
    Journal: J Chromatogr B Analyt Technol Biomed Life Sci; 2008 Dec 15; 876(2):277-82. PubMed ID: 19026601.
    Abstract:
    A HPLC-tandem mass spectrometry method was developed and validated for the quantitation of intact oxaliplatin in human plasma. Plasma ultrafiltrates were precipitated with acetonitrile and separation was performed on a 250 mm Beckman ODS reverse phase column using a gradient mobile phase. The mass spectrometer was operated in positive ionization mode using TurboionSpray and precursor-product ion combinations of m/z 391.1-->305.1 and 371.1-->247.0 were monitored for oxaliplatin and carboplatin, the internal standard, respectively. The lower limit of quantitation for oxaliplatin was 20 ng/ml. The linear range of the method was 20-1000 ng/ml. The between- and within-day relative standard deviations ranged from 3.1 to 7.7%, and accuracy was within 5%. This method was successfully applied in a clinical study of oxaliplatin.
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