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  • Title: Pleuromutilin derivatives having a purine ring. Part 2: influence of the central spacer on the antibacterial activity against Gram-positive pathogens.
    Author: Hirokawa Y, Kinoshita H, Tanaka T, Nakamura T, Fujimoto K, Kashimoto S, Kojima T, Kato S.
    Journal: Bioorg Med Chem Lett; 2009 Jan 01; 19(1):170-4. PubMed ID: 19028096.
    Abstract:
    Structural modification of the 4-piperidinethio moiety, as a spacer of the first pleuromutilin analogues 2A and 2B having a purine ring, led to discovery of the novel pleuromutilin derivatives 14B and 17B. These compounds with good solubility in water showed promising in vitro antibacterial activity against various Gram-positive bacteria including MRSA, PRSP, and VRE and have potent in vivo efficacy.
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