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  • Title: Interferons in chronic viral hepatitis.
    Author: Müller R.
    Journal: Hepatogastroenterology; 1991 Feb; 38(1):4-9. PubMed ID: 1902816.
    Abstract:
    Interferons represent the rapid defence system against viral infections. This review describes the types of interferon and their effects on chronic viral hepatitis. The role of interferon therapy for hepatitis B has been intensively evaluated over the last few years. Response rates of approximately 30% can be achieved by a 4- to 6-month course of alpha interferon treatment in non-immunosuppressed Caucasian patients. Assessment of interferon therapy for hepatitis C has had to rely on indirect markers of disease activity. Current data available indicate response rates in terms of aminotransferase activities of about 50% of patients treated. However, relapse after discontinuation of alpha interferon treatment is common. At present there is no valid treatment procedure for chronic hepatitis D infection. Only a minority of patients with chronic hepatitis D appears to benefit even transiently from alpha interferon.
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