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  • Title: Correlation of expression levels of BLyS and its receptors with multiple myeloma.
    Author: Ju S, Wang Y, Ni H, Wang X, Jiang P, Kong X, Zhong R.
    Journal: Clin Biochem; 2009 Mar; 42(4-5):387-99. PubMed ID: 19028483.
    Abstract:
    OBJECTIVES: To measure the expression levels of B-lymphocyte stimulator (BLyS) and its receptors in multiple myeloma (MM), and to investigate the relationship between them. DESIGN AND METHODS: BLyS and its receptors mRNA levels from peripheral blood mononuclear cells (PBMCs) of 31 MM patients and 30 healthy controls were determined by real-time PCR. The results were presented as the ratios of target genes, to beta(2)-microglobulin (beta(2)M), mRNA. BLyS serum level was determined by enzyme-linked immunosorbent assay (ELISA). RESULTS: The circulating levels of BLyS in 31 MM patients were significantly elevated and correlated with the levels of Lactate dehydrogenase (LDH). More importantly, 93.55% (29/31) and 90.32% (28/31) of these MM patients had significantly higher expression levels of BLyS and BCMA mRNA respectively, which are correlated with the levels of LDH, while 64.52% (20/31) of these MM patients had significantly lower expression levels of TACI mRNA. CONCLUSION: BLyS protein concentration and BLyS, TACI and BAFF-R mRNA expression levels were significantly elevated in patients with MM, suggesting that BLyS, TACI and BAFF-R may be involved in the pathogenesis of MM, and that expression levels could serve as a biomarker of prognosis.
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