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  • Title: Peripheral B cell abnormalities and disease activity in systemic lupus erythematosus.
    Author: Hostmann A, Jacobi AM, Mei H, Hiepe F, Dörner T.
    Journal: Lupus; 2008 Dec; 17(12):1064-9. PubMed ID: 19029273.
    Abstract:
    Autoreactive B cells and plasma cells appear to be of central importance in the pathogenesis of systemic lupus erythematosus (SLE) characterized by a plethora of autoantibodies. Recent insights into abnormalities of B cell and plasma cell compartments in human SLE have identified a number of cellular disturbances within these compartments that in part correlate with the disease activity. This review discusses these findings and the potential underlying extrinsic and/or intrinsic influences apparently driving general B cell activation in this entity.
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