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  • Title: Origin, homeostasis and function of Langerhans cells and other langerin-expressing dendritic cells.
    Author: Merad M, Ginhoux F, Collin M.
    Journal: Nat Rev Immunol; 2008 Dec; 8(12):935-47. PubMed ID: 19029989.
    Abstract:
    Langerhans cells (LCs) are a specialized subset of dendritic cells (DCs) that populate the epidermal layer of the skin. Langerin is a lectin that serves as a valuable marker for LCs in mice and humans. In recent years, new mouse models have led to the identification of other langerin(+) DC subsets that are not present in the epidermis, including a subset of DCs that is found in most non-lymphoid tissues. In this Review we describe new developments in the understanding of the biology of LCs and other langerin(+) DCs and discuss the challenges that remain in identifying the role of different DC subsets in tissue immunity.
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