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  • Title: Frequency of the severe combined immunodeficiency disease gene among horses in Morocco.
    Author: Piro M, Benjouad A, Tligui NS, El Allali K, El Kohen M, Nabich A, Ouragh L.
    Journal: Equine Vet J; 2008 Sep; 40(6):590-1. PubMed ID: 19031514.
    Abstract:
    Severe combined immunodeficiency disease (SCID) of horses is an autosomal, recessive hereditary disease occurring among Arabian or crossbred Arabian horses. The genetic defect responsible was previously identified as a 5-base pair deletion in the gene encoding the catalytic subunit of the DNA dependant protein kinase (DNA-PKcs). This study was carried out to determine the frequency of SCID and identify horses carrying the gene for SCID among Arabian and Arabian crossbred stallions and mares in Morocco using a DNA-based test. Twenty-one horses were SCID carriers: 14 (7%) Arabians, 6 (4%) Arab-Barbs and one (33%) Anglo-Arab. After analysing their genealogy, 3 imported stallions were identified that disseminated the mutant gene of DNA-PKcs in Morocco.
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