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  • Title: Ha-Ras augments c-Jun activity and stimulates phosphorylation of its activation domain.
    Author: Binétruy B, Smeal T, Karin M.
    Journal: Nature; 1991 May 09; 351(6322):122-7. PubMed ID: 1903181.
    Abstract:
    Ha-Ras augments c-Jun-mediated transactivation by potentiating the activity of the c-Jun activation domain. Ha-Ras also causes a corresponding increase in phosphorylation of specific sites in that part of the c-Jun protein. A Ha-Ras-induced protein kinase cascade resulting in hyperphosphorylation of the c-Jun activation domain could explain how these oncoproteins cooperate to transform rat embryo fibroblasts.
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