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  • Title: 1,2-hydroxypyridonate/terephthalamide complexes of gadolinium(III): synthesis, stability, relaxivity, and water exchange properties.
    Author: Werner EJ, Kozhukh J, Botta M, Moore EG, Avedano S, Aime S, Raymond KN.
    Journal: Inorg Chem; 2009 Jan 05; 48(1):277-86. PubMed ID: 19032045.
    Abstract:
    Four new Gd(III) complexes based on the 1,2-hydroxypyridinone chelator have been synthesized and evaluated as potential magentic resonance imaging contrast agents. Previously reported work examining Gd-TREN-1,2-HOPO (3; HOPO = hydroxypyridinone) suggests that the 1,2-HOPO unit binds strongly and selectively to Gd(III), encouraging further study of the stability and relaxivity properties of this class of compounds. Among the new complexes presented in this paper are the homopodal Gd-Ser-TREN-1,2-HOPO (Gd-5) and three heteropodal bis-1,2-HOPO-TAM complexes (Gd-6, Gd-7, and Gd-8; TAM = terephthalamide). Conditional stability constants were determined, and all pGd values are in the range of 18.5-19.7, comparable to other analogous HOPO complexes and currently used commercial contrast agents. Relaxivities for all complexes are about twice those of commercial agents, ranging from 7.8 to 10.5 mM(-1) s(-1) (20 MHz; 25 degrees C), and suggest two innersphere water molecules in fast exchange. Luminescent measurements were used to verify the number of coordinated waters for Gd-5, and VT (17)O NMR experiments were employed for the highly soluble Gd-TREN-bis-1,2-HOPO-TAM-N3 (Gd-8) complex to measure a fast water exchange rate, (298)k(ex) = 1/tau(M), of 5.1 (+/-0.4) x 10(8) s(-1) ((298)tau(M) approximately 2 ns).
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