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  • Title: Interferon-gamma enhances PAF-acether production by stimulated human polymorphonuclear leucocytes.
    Author: Geffner JR, Schattner MA, Lazzari MA, Isturiz MA.
    Journal: Scand J Immunol; 1991 May; 33(5):575-8. PubMed ID: 1903211.
    Abstract:
    Human polymorphonuclear leucocytes (PMN) stimulated with either immune complexes (IC), phorbol myristate acetate (PMA) or N-formyl-methionyl-leucyl-phenylalanine (FMLP) generate platelet-activating factor (PAF-acether). The present study demonstrates that treatment of PMN with recombinant human interferon-gamma (IFN-gamma) significantly enhanced the production of PAF-acether by stimulated cells, in a concentration-dependent mode. On the contrary, alpha and beta IFN were completely unable to increase PAF-acether synthesis by stimulated PMN. The significance of these results is discussed.
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