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  • Title: Synthesis, antiplatelet and vasorelaxing activities of xanthone derivatives.
    Author: Lin KW, Fang SC, Hung CF, Shieh BJ, Yang SC, Teng CM, Lin CN.
    Journal: Arch Pharm (Weinheim); 2009 Jan; 342(1):19-26. PubMed ID: 19035386.
    Abstract:
    A series of omega-aminoalkoxylxanthones was synthesized and tested in vitro for their ability to inhibit platelet aggregation and cause vasorelaxing action. Compounds 4, 5, 12, 17, and 18 showed significant antiplatelet effects on thrombin-, arachidonic acid (AA)-, collagen-, and platelet activating factor (PAF)-induced washed rabbit platelet aggregation and exhibited inhibition of primary and secondary aggregation induced by adenosine-5'-diphosphate (ADP) in human platelet-rich-plasma (PRP). Compounds 4, 17, and 18 revealed vasorelaxing activities in rat thoracic aorta. We concluded that these compounds may be developed as new antithrombotic agents.
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