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  • Title: One-pot tandem double-aldol reaction/aza-addition of acetylacetamides and o-phthalaldehyde leading to spiroindan-2,2'-pyrrolidines.
    Author: Cheng X, Liang F, Shi F, Zhang L, Liu Q.
    Journal: Org Lett; 2009 Jan 01; 11(1):93-6. PubMed ID: 19035841.
    Abstract:
    A novel domino reaction based on o-phthalaldehyde and 3-oxo-N-arylbutanamide 1 has been developed which allows one-pot and efficient synthesis of structurally complex spiroindan-2,2'-pyrrolidines 2 and 3 with complete regioselectivity and high stereoselectivity from acyclic precursors.
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