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  • Title: Acute multifocal placoid pigment epitheliopathy associated with erythema nodosum and a flu-like illness.
    Author: Senanayake SN, Selvadurai S, Hawkins CA, Tridgell D.
    Journal: Singapore Med J; 2008 Nov; 49(11):e333-5. PubMed ID: 19037545.
    Abstract:
    Acute multifocal placoid pigment epitheliopathy (AMPPE) is a rare inflammatory vasculitis of the choroid. Despite primarily being a disorder of the eye, a number of extra-ophthalmological features have been described in AMPPE and may accompany the visual disturbances. Such patients may be admitted under the care of physicians for evaluation of a systemic illness. We report AMPPE occurring in a 37-year-old man in his thirties admitted with a flu-like illness, erythema nodosum, visual disturbances and raised inflammatory markers. Conditions such as bacterial endocarditis and vasculitis, were considered before a diagnosis of AMPPE was made. The case illustrates how AMPPE can be a diagnostic dilemma, particularly when associated with extra-ophthalmological features. The epidemiology, clinical features, diagnosis and therapy of AMPPE are also discussed.
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