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  • Title: Triterpenoid saponins from Ardisia pusilla and their cytotoxic activity.
    Author: Tian Y, Tang HF, Qiu F, Wang XJ, Chen XL, Wen AD.
    Journal: Planta Med; 2009 Jan; 75(1):70-5. PubMed ID: 19039733.
    Abstract:
    Three new triterpenoid saponins 3, 4 and 5, together with two known saponins, ardisiacrispin B (1) and ardisiacrispin A (2), were isolated from the whole plants of Ardisia pusilla A. DC. Their structures were elucidated by extensive spectral analysis and chemical evidence. Compound 3 is a hexaglycoside with a 13,28-epoxyoleanane type aglycone, while both 4 and 5 are triterpenoid tetraglycosides related to the olean-12-ene skeleton. Saponins 1-4 exhibited significant cytotoxicity against human glioblastoma U251MG cells, but did not affect the growth of primary cultured human astrocytes.
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