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  • Title: Molecular cloning of Kazal-type proteinase inhibitor of the shrimp Fenneropenaeus chinensis.
    Author: Kong HJ, Cho HK, Park EM, Hong GE, Kim YO, Nam BH, Kim WJ, Lee SJ, Han HS, Jang IK, Lee CH, Cheong J, Choi TJ.
    Journal: Fish Shellfish Immunol; 2009 Jan; 26(1):109-14. PubMed ID: 19041263.
    Abstract:
    Proteinase inhibitors play important roles in host defence systems involving blood coagulation and pathogen digestion. We isolated and characterized a cDNA clone for a Kazal-type proteinase inhibitor (KPI) from a hemocyte cDNA library of the oriental white shrimp Fenneropenaeus chinensis. The KPI gene consists of three exons and two introns. KPI cDNA contains an open reading frame of 396 bp, a polyadenylation signal sequence AATAAA, and a poly (A) tail. KPI cDNA encodes a polypeptide of 131 amino acids with a putative signal peptide of 21 amino acids. The deduced amino acid sequence of KPI contains two homologous Kazal domains, each with six conserved cysteine residues. The mRNA of KPI is expressed in the hemocytes of healthy shrimp, and the higher expression of KPI transcript is observed in shrimp infected with the white spot syndrome virus (WSSV), suggesting a potential role for KPI in host defence mechanisms.
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