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  • Title: Preclinical detection of Parkinson's disease: biochemical approaches.
    Author: Parker WD.
    Journal: Neurology; 1991 May; 41(5 Suppl 2):34-6; discussion 36-7. PubMed ID: 1904140.
    Abstract:
    Dysfunction of NADH: ubiquinone oxidoreductase (complex I) of the mitochondrial electron transport chain has been linked to the pathogenesis of Parkinson's disease. While simple assays of complex I activity are unlikely to be useful in the preclinical detection of Parkinson's disease, other more sophisticated physical-chemical approaches including detection of free radical damage may have utility. Leber's hereditary optic neuropathy may provide a useful model system for development of such strategies.
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