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  • Title: A cholesterol toggle switch.
    Author: Hampton RY.
    Journal: Cell Metab; 2008 Dec; 8(6):451-3. PubMed ID: 19041760.
    Abstract:
    Cholesterol levels in mammalian cells are controlled by an intricate mechanism in which the transcription factor SREBP plays a key role. Work in this issue (Radhakrishnan et al., 2008) employing direct measurement of endoplasmic reticulum cholesterol levels offers insights into the "switch" that controls this system with surprising precision.
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