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  • Title: [A case of amyotrophic lateral sclerosis with disturbance of vertical ocular movement responding to thyrotropin releasing hormone (TRH)].
    Author: Nemoto H, Yoshimura M, Kurihara T, Kinoshita M.
    Journal: Rinsho Shinkeigaku; 1991 Jan; 31(1):84-6. PubMed ID: 1904337.
    Abstract:
    A 64-year-old woman who had amyotrophic lateral sclerosis (ALS) with disturbance of vertical ocular movement was presented. She was admitted to our hospital with progressive dysphagia, dysarythria and weakness of the extremities. Neurological examinations revealed disturbance of vertical ocular movement with normal doll's eye phenomenon (supranuclear origin), bulbar palsy, muscle weakness of the extremities, extensor plantar signs, and fasciculations of the costal and interosseal muscles. EMG studies showed denervation potentials, and muscle biopsy demonstrated group atrophy, fiber type grouping and small angular fibers. TRH injections resulted in improvement of disturbance of vertical ocular movement, but no effect was seen on the weakness of the limb. There was about 20 Japanese cases with disturbance of ocular movement in ALS, but it was rare to see ocular movement disorder from the early stage of ALS. The pathophysiology of ocular movement disorder in ALS has been thought to be due to supranuclear origin, i.e., the disturbance in the pathway from the frontal cortex to the mesencephalon. In this case, TRH might effect at some point of the frontomesencephalic pathway.
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