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  • Title: [Case of interstitial pneumonia induced by intravesical administration of Bacillus Calmette-Guerin].
    Author: Yamamoto A, Koyama R, Kido K, Koike K, Toba M, Takahashi K.
    Journal: Nihon Kokyuki Gakkai Zasshi; 2008 Oct; 46(10):803-7. PubMed ID: 19044030.
    Abstract:
    An 81-year-old man with superficial bladder cancer, which was detected after he complained of hematuria and pain on urination, was treated 5 times with intravesical bacillus Calmette-Guerin (BCG) administration. Since he complained of a dry cough and dyspnea associated with severe hypoxemia, and had extensive bilateral pulmonary infiltrative shadows on his chest X-ray film, he was admitted to our hospital. He was treated with methylprednisolone under a diagnosis of interstitial pneumonia. Because BCG infection and/or bacterial pneumonia could not be denied, we administered antituberculosis agent and antibiotics. However, he died due to respiratory failure on 10th day after admission. Because a lymphocyte stimulation test for BCG was strongly positive, we established a diagnosis of interstitial pneumonia induced by intravesical administration of BCG. Because the mortality rate is high, the evaluation of interstitial pneumonia before administration of BCG is crucial.
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