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  • Title: Short course of radiation therapy in elderly patients with glioblastoma multiforme.
    Author: Idbaih A, Taillibert S, Simon JM, Psimaras D, Schneble HM, Lopez S, Lang P, Toubiana T, Feuvret L, Delattre JY, Mazeron JJ.
    Journal: Cancer Radiother; 2008 Dec; 12(8):788-92. PubMed ID: 19046921.
    Abstract:
    PURPOSE: The optimal schedule of irradiation in elderly patients suffering from glioblastoma multiforme (GBM) is unsettled. MATERIALS AND METHODS: This study reviewed the charts of 28 consecutive GBM patients aged 70 years or more with a Karnofsky Performance Status (KPS) greater than or equal to 70 who received a short course of radiotherapy (40 grays in 15 fractions over three weeks). RESULTS: The median age at surgery was 74.6 years (range, 70.1-85.7). No patient received prior or concomitant chemotherapy. The median progression-free survival and overall survival were 21.6 weeks (95% CI, 17.0-39.9) and 50.6 weeks (95% CI, 26.3-62.0), respectively. Even within a narrow range (<90 or >or=90), KPS remained a prognostic factor (p=0.03). Tolerance appeared acceptable in terms of KPS changes and corticosteroid use during radiation therapy. CONCLUSION: These results support the efficacy of short schedule radiotherapy for GBM in elderly patients with a good KPS.
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