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  • Title: Specificity of guanylic RNases to polynucleotide substrates.
    Author: Both V, Moiseyev GP, Sevcik J.
    Journal: Biochem Biophys Res Commun; 1991 Jun 14; 177(2):630-5. PubMed ID: 1904722.
    Abstract:
    Kinetic parameters kcat and KM were measured for cleavage of poly I, poly A, poly U, poly C and poly I poly C by guanyl-specific RNases Sa, Pb1 and T1 and compared with that of guanyl-preferential RNase Bi. Catalytic efficiencies of the investigated enzymes to polynucleotide substrates vary considerably. The structural basis for specificity of these RNases is discussed. A hypothesis is suggested that Ser-56 plays an important role in recognition of poly A by RNase Bi.
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