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  • Title: Control of components of bacterial polysaccharide vaccines by physical methods.
    Author: Jones C, Currie F.
    Journal: Biologicals; 1991 Jan; 19(1):41-7. PubMed ID: 1904745.
    Abstract:
    Analysis of polysaccharide components of meningococcal- and pneumococcal vaccines was carried out by proton n.m.r. spectroscopy and gas chromatography. The meningococcal polysaccharides were of high purity but showed differences in degree and position of O-acetylation between manufacturers. The level of contamination of the pneumococcal polysaccharides by C-substance was quantified. These methods provide an alternative to immunological methods for determining serotype and purity.
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