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  • Title: [Sideroblastic anemia after prolonged linezolid therapy].
    Author: Kakimoto T, Nakazato T, Miura R, Kurai H, Yamashita D, Sagara Y, Ishida A.
    Journal: Rinsho Ketsueki; 2008 Nov; 49(11):1566-8. PubMed ID: 19047790.
    Abstract:
    Linezolid is an effective and well-tolerated antibiotic for the treatment of infections caused by Gram-positive pathogens. Some reports have shown that linezolid treatment for more than 2 weeks has been associated with reversible bone marrow suppression, especially thrombocytopenia and anemia. We encountered a case of sideroblastic anemia following prolonged linezolid therapy in a laryngeal cancer patient. He received linezolid therapy for multiple abscesses due to MRSA. Before treatment, the Hb level was 12.5 g/dl and then slowly decreased to 5.9 g/dl for 2 months during treatment. Ringed sideroblasts were detected in the bone marrow. Linezolid was discontinued and the Hb level was slowly increased. This case was considered to reflect a rare complication of linezolid therapy.
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