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  • Title: A ratiometric fluorescent probe for cysteine and homocysteine displaying a large emission shift.
    Author: Lin W, Long L, Yuan L, Cao Z, Chen B, Tan W.
    Journal: Org Lett; 2008 Dec 18; 10(24):5577-80. PubMed ID: 19053722.
    Abstract:
    4-(1H-phenanthro[9,10-d]imidazol-2-yl)benzaldehyde 1 was rationally designed as a novel ratiometric fluorescent probe for cysteine and homocysteine. Upon addition of cysteine or homocysteine, notably, the probe displayed a very large (125 nm) hypsochromic shift in emission due to switching off intramolecular charge transfer. This large emission wavelength shift may allow probe 1 to be employed for quantitatively detecting Cys/Hcy.
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