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  • Title: Proteomic analysis of HepaRG cells: a novel cell line that supports hepatitis B virus infection.
    Author: Narayan R, Gangadharan B, Hantz O, Antrobus R, García A, Dwek RA, Zitzmann N.
    Journal: J Proteome Res; 2009 Jan; 8(1):118-22. PubMed ID: 19053806.
    Abstract:
    The first proteomic characterization of the HepaRG cell line, the only cell line that is susceptible to hepatitis B virus (HBV) infection and supports a complete virus life cycle, is reported. Differential analysis of naive and HBV-infected HepaRG cells by two-dimensional gel electrophoresis revealed 19 differentially regulated features, 7 increasing and 12 decreasing with HBV infection. The proteins identified in these features were involved in various cellular pathways including apoptosis, DNA/RNA processing, and hepatocellular impairment. Similar expression changes in a number of the identified proteins have already been reported for other virus systems. Identification of these expression changes is a validation of the proteomics approach and contributes to an understanding of host cellular response to HBV infection.
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