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  • Title: Glycosaminoglycans in the synovial fluids of patients with juvenile rheumatoid arthritis.
    Author: Spelling PF, Heise N, Toledo OM.
    Journal: Clin Exp Rheumatol; 1991; 9(2):195-9. PubMed ID: 1905599.
    Abstract:
    A simple method was used to isolate hyaluronic acid (HA) and sulfated glycosaminoglycans from synovial fluids obtained from children with juvenile rheumatoid arthritis (JRA) and from normal age-matched controls. The bulk of the glycosaminoglycans present in both normal and pathologic synovial fluids consisted of hyaluronic acid and chondroitin 6-sulfate. The diseased synovial fluids showed a sharp decrease in the concentration of glycosaminoglycans when compared with normal controls. These findings are similar to those reported for the synovial fluid of adult patients with rheumatoid arthritis.
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