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  • Title: Proteomics-based approach to elucidate the mechanism of antitumor effect of curcumin in cervical cancer.
    Author: Madden K, Flowers L, Salani R, Horowitz I, Logan S, Kowalski K, Xie J, Mohammed SI.
    Journal: Prostaglandins Leukot Essent Fatty Acids; 2009 Jan; 80(1):9-18. PubMed ID: 19058955.
    Abstract:
    Cervical cancer is the second leading cause of cancer death for women in the world. A potential target for preventing and treating cervical cancer is cyclooxygenase-2 (cox-2). Curcumin is an anti-inflammatory agent that is known to have anti-cox-2 activity. In this study we examined the expression of cox-2 in cervical cancer and its precursors by immunohistochemistry. The effect of curcumin in inhibiting cervical cancer cells was determined via 2-dimensional gel electrophoresis, data analysis, and ingenuity pathway analysis. No significant differences in the expression of cox-2 in squamous cell carcinoma, and carcinoma in situ were observed. However, there was a statistically significant difference in the expression of cox-2 in adenocarcinoma in comparison to normal (p value=0.01) and squamous cell carcinoma (p value=0.02) tissues. Proteins associated with cancer and cell cycle were significantly altered in cultured cells. Curcumin may have antitumor effect in cervical cancer.
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