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  • Title: L-tyrosine induces tyrosinase expression via a posttranscriptional mechanism.
    Author: Slominski A, Costantino R.
    Journal: Experientia; 1991 Jul 15; 47(7):721-4. PubMed ID: 1906010.
    Abstract:
    Exposure of hamster amelanotic melanoma cells to L-tyrosine caused a time-dependent increase of tyrosinase protein concentrations, tyrosinase activity and level of cell pigmentation. In contrast, Northern blot analysis using mouse tyrosinase cDNA showed a steady level of tyrosinase mRNA. Thus in hamster melanoma cells the stimulation of intracellular tyrosinase concentration by L-tyrosine is mediated mainly via a posttranscriptional mechanism.
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