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  • Title: Practical method for asymmetric addition of arylboronic acids to alpha,beta-unsaturated carbonyl compounds utilizing an in situ prepared rhodium catalyst.
    Author: Lukin K, Zhang Q, Leanna MR.
    Journal: J Org Chem; 2009 Jan 16; 74(2):929-31. PubMed ID: 19061408.
    Abstract:
    A new practical method for the asymmetric Michael addition of arylboronic acids to alpha,beta-unsaturated carbonyl compounds utilizing in situ generated chiral rhodium-binap-based catalyst has been developed to address the unavailability of the preformed catalysts. While maintaining high levels of enantioselectivity reported for the preformed catalysts, the new method provides a convenient access to either enantiomeric form of the product and allows for a substantial reductions in both the boronic acid and the catalyst loads.
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