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  • Title: Early follicle development alters the relationship between antral follicle counts and inhibin B and follicle-stimulating hormone levels on cycle day 3.
    Author: Grynberg M, Feyereisen E, Scheffer JB, Koutroubis P, Frydman R, Fanchin R.
    Journal: Fertil Steril; 2010 Feb; 93(3):894-9. PubMed ID: 19061996.
    Abstract:
    OBJECTIVE: To verify whether, during the luteal-follicular transition, increased inhibin B production by abnormally large follicles modifies the expected relationship between the number of follicles and peripheral inhibin B and FSH levels. DESIGN: Prospective study. SETTING: Teaching hospital, France. PATIENT(S): A total of 192 normo-ovulatory women. INTERVENTION(S): Serum inhibin B and FSH levels and numbers and sizes of antral follicles (3-12 mm) were measured on cycle day 3. MAIN OUTCOME MEASURE(S): The strength of hormonal-follicular correlations was assessed in two groups formed according to the presence (large follicle group; n = 73) or absence (small follicle group; n = 119) of one follicle measuring >7 mm. RESULT(S): Serum inhibin B and FSH levels were correlated with antral follicle counts (r = 0.32 and r = -0.44, respectively). These relationships were significantly weaker in the large follicle group (r = 0.24 and r = -0.28, respectively) than in the small follicle group (r = 0.51 and r = -0.55, respectively). CONCLUSION(S): Antral follicle size influences serum inhibin B and FSH levels and alters their expected relationship with the number of antral follicles on day 3. These results contribute to clarifying the controversial role of serum inhibin B and FSH levels in the prediction of ovarian follicular status.
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