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  • Title: Can intracytoplasmic morphologically selected sperm injection be used to select normal-sized sperm heads in infertile patients with macrocephalic sperm head syndrome?
    Author: Chelli MH, Albert M, Ray PF, Guthauser B, Izard V, Hammoud I, Selva J, Vialard F.
    Journal: Fertil Steril; 2010 Mar 01; 93(4):1347.e1-5. PubMed ID: 19062000.
    Abstract:
    OBJECTIVE: To study the chromosomal content of spermatozoa selected by intracytoplasmic morphologically selected sperm injection (IMSI) in cases of macrocephalic sperm head syndrome. DESIGN: Case report. SETTING: Obstetrics, gynecology, urology, and reproductive biology departments. PATIENT(S): Two infertile patients with large-headed spermatozoa. INTERVENTION(S): Fluorescence in situ hybridization on selected spermatozoa with normal-sized heads after IMSI selection. MAIN OUTCOME MEASURE(S): Percentages of polyploid, diploid, haploid aneuploid, and normal spermatozoa. RESULT(S): Of the six spermatozoa that could be selected, all were haploid but aneuploid. CONCLUSION(S): Absence of normal haploid spermatozoa among high magnification-selected spermatozoa contraindicated IMSI for these two patients.
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