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  • Title: Fixed drug eruption: a prototypic disorder mediated by effector memory T cells.
    Author: Mizukawa Y, Shiohara T.
    Journal: Curr Allergy Asthma Rep; 2009 Jan; 9(1):71-7. PubMed ID: 19063828.
    Abstract:
    Effector memory T cells are uniquely specialized to mediate protective immunity. However, their excessive activation may result in the development of organ-specific inflammatory diseases, which have not been extensively studied. Fixed drug eruption (FDE), a localized variant of drug-induced dermatoses characterized by relapse in the same location, is a prototypic disorder mediated by excessive activation of effector memory T cells, which are resident in the lesional epidermis. A variety of clinical and pathologic features uniquely observed in FDE lesions can be explained by the presence of CD8(+) intraepidermal T cells with the effector memory phenotype in the FDE lesion. This review focuses on how these T cells are generated, retained in the epidermis, and activated to cause epidermal damage.
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